Research ArticleCancer
Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)
- Emiliano Cocco1,*,
- F. Javier Carmona1,*,
- Pedram Razavi1,2,
- Helen H. Won1,3,
- View ORCID ProfileYanyan Cai1,3,
- View ORCID ProfileValentina Rossi4,
- View ORCID ProfileCarmen Chan1,
- James Cownie1,
- View ORCID ProfileJoanne Soong1,
- View ORCID ProfileEneda Toska1,
- View ORCID ProfileSophie G. Shifman1,
- View ORCID ProfileIvana Sarotto5,
- View ORCID ProfilePeter Savas6,
- View ORCID ProfileMichael J. Wick7,
- View ORCID ProfileKyriakos P. Papadopoulos7,
- Alyssa Moriarty7,
- Richard E. Cutler Jr.8,
- View ORCID ProfileFrancesca Avogadri-Connors8,
- Alshad S. Lalani8,
- Richard P. Bryce8,
- View ORCID ProfileSarat Chandarlapaty1,2,
- View ORCID ProfileDavid M. Hyman2,
- View ORCID ProfileDavid B. Solit1,2,9,
- View ORCID ProfileValentina Boni10,
- View ORCID ProfileSherene Loi6,
- View ORCID ProfileJosé Baselga1,2,
- View ORCID ProfileMichael F. Berger1,3,
- View ORCID ProfileFilippo Montemurro4,†, and
- View ORCID ProfileMaurizio Scaltriti1,3,†
- 1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
- 2Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
- 3Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
- 4Unit of Investigative Clinical Oncology (INCO), Candiolo Cancer Institute, FPO-IRCCS, Str. Provinciale 142, 10060 Candiolo, Italy.
- 5Unit of Surgical Pathology, Fondazione del Piemonte per l’Oncologia, Candiolo Cancer Institute, FPO-IRCCS, Str. Provinciale 142, 10060 Candiolo, Italy.
- 6Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC 3000, Australia.
- 7START, 4383 Medical Dr, San Antonio, TX 78229, USA.
- 8Puma Biotechnology Inc., 10880 Wilshire Blvd, Los Angeles, CA 90024, USA.
- 9Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
- 10START Madrid, Centro Integral Oncológico Clara Campal, Hospital Universitario Madrid Sanchinarro, Calle de Oña 10, 28050 Madrid, Spain.
- ↵†Corresponding author. Email: filippo.montemurro{at}ircc.it (F.M.); scaltrim{at}mskcc.org (M.S.)
↵* These authors contributed equally to this work.
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Science Signaling 09 Oct 2018:
Vol. 11, Issue 551, eaat9773
DOI: 10.1126/scisignal.aat9773
Vol. 11, Issue 551, eaat9773
DOI: 10.1126/scisignal.aat9773
Emiliano Cocco
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
F. Javier Carmona
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Pedram Razavi
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
2Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Helen H. Won
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
3Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Yanyan Cai
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
3Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Valentina Rossi
4Unit of Investigative Clinical Oncology (INCO), Candiolo Cancer Institute, FPO-IRCCS, Str. Provinciale 142, 10060 Candiolo, Italy.
Carmen Chan
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
James Cownie
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Joanne Soong
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Eneda Toska
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Sophie G. Shifman
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Ivana Sarotto
5Unit of Surgical Pathology, Fondazione del Piemonte per l’Oncologia, Candiolo Cancer Institute, FPO-IRCCS, Str. Provinciale 142, 10060 Candiolo, Italy.
Peter Savas
6Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC 3000, Australia.
Michael J. Wick
7START, 4383 Medical Dr, San Antonio, TX 78229, USA.
Kyriakos P. Papadopoulos
7START, 4383 Medical Dr, San Antonio, TX 78229, USA.
Alyssa Moriarty
7START, 4383 Medical Dr, San Antonio, TX 78229, USA.
Richard E. Cutler Jr.
8Puma Biotechnology Inc., 10880 Wilshire Blvd, Los Angeles, CA 90024, USA.
Francesca Avogadri-Connors
8Puma Biotechnology Inc., 10880 Wilshire Blvd, Los Angeles, CA 90024, USA.
Alshad S. Lalani
8Puma Biotechnology Inc., 10880 Wilshire Blvd, Los Angeles, CA 90024, USA.
Richard P. Bryce
8Puma Biotechnology Inc., 10880 Wilshire Blvd, Los Angeles, CA 90024, USA.
Sarat Chandarlapaty
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
2Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
David M. Hyman
2Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
David B. Solit
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
2Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
9Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Valentina Boni
10START Madrid, Centro Integral Oncológico Clara Campal, Hospital Universitario Madrid Sanchinarro, Calle de Oña 10, 28050 Madrid, Spain.
Sherene Loi
6Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC 3000, Australia.
José Baselga
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
2Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Michael F. Berger
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
3Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Filippo Montemurro
4Unit of Investigative Clinical Oncology (INCO), Candiolo Cancer Institute, FPO-IRCCS, Str. Provinciale 142, 10060 Candiolo, Italy.
Maurizio Scaltriti
1Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
3Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
