Research ArticleCancer The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential View ORCID ProfileMin-Kyung Choo1, Stefan Kraft2, View ORCID ProfileCaterina Missero3,4, and View ORCID ProfileJin Mo Park1,*1Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.2Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.3CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.4Department of Biology, University of Naples Federico II, 80126 Napoli, Italy.↵*Corresponding author. Email: jmpark{at}cbrc2.mgh.harvard.edu See allHide authors and affiliations Science Signaling 09 Oct 2018:Vol. 11, Issue 551, eaau0727DOI: 10.1126/scisignal.aau0727 Min-Kyung Choo 1Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Min-Kyung Choo Stefan Kraft 2Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Caterina Missero 3CEINGE Biotecnologie Avanzate, 80145 Napoli, Italy.4Department of Biology, University of Naples Federico II, 80126 Napoli, Italy.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Caterina Missero Jin Mo Park 1Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jin Mo Park For correspondence: jmpark@cbrc2.mgh.harvard.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 11 no. 551 DOI: https://doi.org/10.1126/scisignal.aau0727 PubMed: 30301786 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received May 3, 2018Accepted September 14, 2018 . Copyright & Usage: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: October 2018 to March 2021 AbstractFullPdf Oct 20184806424187 Nov 20181344922 Dec 201873214 Jan 201960216 Feb 201962177 Mar 2019691812 Apr 201931197 May 201946188 Jun 201945105 Jul 201928128 Aug 201927113 Sep 20192584 Oct 201973032 Nov 20193356 Dec 201923410 Jan 202024610 Feb 202013212 Mar 202005614 Apr 202004721 May 202033613 Jun 202026715 Jul 202004219 Aug 20201279 Sep 202007119 Oct 202005515 Nov 202014315 Dec 202014617 Jan 20213448 Feb 202117123 Mar 20213206 View Full Text
The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential By Min-Kyung Choo, Stefan Kraft, Caterina Missero, Jin Mo Park Science Signaling09 Oct 2018 The kinase p38α restrains skin stem cell–associated tumorigenesis by inhibiting p63. Supplementary Materials
The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential By Min-Kyung Choo, Stefan Kraft, Caterina Missero, Jin Mo Park Science Signaling09 Oct 2018 The kinase p38α restrains skin stem cell–associated tumorigenesis by inhibiting p63. Supplementary Materials