Contents
23 October 2018
Vol 11, Issue 553
Vol 11, Issue 553
Editorial
- A call to arms: Unifying the fight against resistance
Collaborative, cross-disciplinary research may rapidly advance the fight against drug resistance.
Research Articles
- Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling
Sphingosine 1-phosphate stimulates the mobilization of EGFR ligands to drive eyelid closure in rat embryos.
- The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation
Sequence differences in the Src family kinase Fgr decrease its autoinhibitory regulation and increase its sensitivity to a myeloproliferative cytokine.
- ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome
The Ca2+ sensor NCS1 promotes ER-mitochondria contact and Ca2+ transfer between these organelles.
Editors' Choice
- Flipping in a kinase fold for AMPylation
The pseudokinase SelO mediates AMPylation instead of phosphorylation due to the flipped orientation of ATP in the active site.
Erratum
About The Cover
Online Cover This week features a Research Article that describes a complex pathway through which the lipid sphingosine 1-phosphate stimulates the mobilization of a growth factor to drive eyelid closure in the rat embryo. The image shows a cross section of an embryonic rat eye as the eyelid primordia migrate over the cornea. The eyelid primordia eventually fuse to protect the eye during birth and early postnatal development. [Image: Bian et al./Science Signaling]