Contents

Research Articles

• Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling

  By Ganlan Bian, Caiyong Yu, Ling Liu, Chao Fang, Kun Chen, Pan Ren, Qian Zhang, Fangfang Liu, Kun Zhang, Qian Xue, Jie Xiang, Hongmin Guo, Jun Song, Yu Zhao, Wutian Wu, Sookja K. Chung, Ruixia Sun, Gong Ju, Jian Wang

  Science Signaling23 Oct 2018 Full AccessRestricted Access

  Sphingosine 1-phosphate stimulates the mobilization of EGFR ligands to drive eyelid closure in rat embryos.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation

  By Kexin Shen, Jamie A. Moroco, Ravi K. Patel, Haibin Shi, John R. Engen, Heather R. Dorman, Thomas E. Smithgall

  Science Signaling23 Oct 2018 Full AccessRestricted Access

  Sequence differences in the Src family kinase Fgr decrease its autoinhibitory regulation and increase its sensitivity to a myeloproliferative cytokine.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• ER-mitochondria cross-talk is regulated by the Ca²⁺ sensor NCS1 and is impaired in Wolfram syndrome

  By Claire Angebault, Jérémy Fauconnier, Simone Patergnani, Jennifer Rieusset, Alberto Danese, Corentin A. Affortit, Jolanta Jagodzinska, Camille Mégy, Mélanie Quiles, Chantal Cazevieille, Julia Korchagina, Delphine Bonnet-Wersinger, Dan Milea, Christian Hamel, Paolo Pinton, Marc Thiry, Alain Lacampagne, Benjamin Delprat, Cécile Delettre

  Science Signaling23 Oct 2018 Full AccessRestricted Access

  The Ca²⁺ sensor NCS1 promotes ER-mitochondria contact and Ca²⁺ transfer between these organelles.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials