Contents
Vol 11, Issue 554
Focus
- The RAS-ERK pathway: A route for couples
Mutants that enhance MEK1 homodimerization increase RAF-ERK signaling and MEK inhibitor resistance (Yuan et al., in 30 October 2018 issue).
Research Articles
- Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis
Cancer-associated mutations in the kinase MEK1 increase its dimerization and stimulate RAF-independent signaling.
- RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger
The kinase RSK2 promotes contractility in smooth muscle cells in resistance arteries.
- Modulation of Cl− signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT
Different phosphorylation patterns regulate the activity of an epithelial transporter and its sensitivity to Cl−.
Editors' Choice
- Pathogen-driven vascularization
A cell wall component of mycobacteria stimulates vascularization of granulomas.
About The Cover

Online Cover This week features a Research Article that shows that the kinase RSK2 promotes contractility in smooth muscle cells in resistance arteries. The image shows the blood vessels in a human leg. [Image: Yibo Wang/shutterstock.com]