Contents

Research Articles

• Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

  By Jimin Yuan, Wan Hwa Ng, Zizi Tian, Jiajun Yap, Manuela Baccarini, Zhongzhou Chen, Jiancheng Hu

  Science Signaling30 Oct 2018 Full AccessRestricted Access

  Cancer-associated mutations in the kinase MEK1 increase its dimerization and stimulate RAF-independent signaling.

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• RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na⁺/H⁺ exchanger

  By Mykhaylo V. Artamonov, Swapnil K. Sonkusare, Miranda E. Good, Ko Momotani, Masumi Eto, Brant E. Isakson, Thu H. Le, Eric L. Cope, Zygmunt S. Derewenda, Urszula Derewenda, Avril V. Somlyo

  Science Signaling30 Oct 2018 Full AccessRestricted Access

  The kinase RSK2 promotes contractility in smooth muscle cells in resistance arteries.

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• Modulation of Cl⁻ signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT

  By Laura Vachel, Nikolay Shcheynikov, Osamu Yamazaki, Moran Fremder, Ehud Ohana, Aran Son, Dong Min Shin, Ai Yamazaki-Nakazawa, Chin-Rang Yang, Mark A. Knepper, Shmuel Muallem

  Science Signaling30 Oct 2018 Full AccessRestricted Access

  Different phosphorylation patterns regulate the activity of an epithelial transporter and its sensitivity to Cl⁻.

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