Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

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  Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

  By Jimin Yuan, Wan Hwa Ng, Zizi Tian, Jiajun Yap, Manuela Baccarini, Zhongzhou Chen, Jiancheng Hu

  Science Signaling30 Oct 2018

  Cancer-associated mutations in the kinase MEK1 increase its dimerization and stimulate RAF-independent signaling.

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  Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

  By Jimin Yuan, Wan Hwa Ng, Zizi Tian, Jiajun Yap, Manuela Baccarini, Zhongzhou Chen, Jiancheng Hu

  Science Signaling30 Oct 2018

  Cancer-associated mutations in the kinase MEK1 increase its dimerization and stimulate RAF-independent signaling.

  • Supplementary Materials

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