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Research ArticleION TRANSPORT
Modulation of Cl− signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT
- Laura Vachel1,*,
- Nikolay Shcheynikov1,*,
- Osamu Yamazaki1,2,*,
- Moran Fremder3,
- Ehud Ohana3,
- View ORCID ProfileAran Son1,
- View ORCID ProfileDong Min Shin4,
- Ai Yamazaki-Nakazawa1,
- Chin-Rang Yang5,
- View ORCID ProfileMark A. Knepper5, and
- Shmuel Muallem1,†
- 1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
- 2Apheresis and Dialysis Center/General Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan.
- 3Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.
- 4Department of Oral Biology, BK 21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea.
- 5Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
- ↵†Corresponding author. Email: shmuel.muallem{at}nih.gov
↵* These authors contributed equally to this work and are first co-authors.
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Science Signaling 30 Oct 2018:
Vol. 11, Issue 554, eaat5018
DOI: 10.1126/scisignal.aat5018
Vol. 11, Issue 554, eaat5018
DOI: 10.1126/scisignal.aat5018
Laura Vachel
1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Nikolay Shcheynikov
1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Osamu Yamazaki
1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
2Apheresis and Dialysis Center/General Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan.
Moran Fremder
3Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.
Ehud Ohana
3Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.
Aran Son
1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Dong Min Shin
4Department of Oral Biology, BK 21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea.
Ai Yamazaki-Nakazawa
1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Chin-Rang Yang
5Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mark A. Knepper
5Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shmuel Muallem
1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
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