Modulation of Cl− signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT

Laura Vachel; Nikolay Shcheynikov; Osamu Yamazaki; Moran Fremder; Ehud Ohana; Aran Son; Dong Min Shin; Ai Yamazaki-Nakazawa; Chin-Rang Yang; Mark A. Knepper; Shmuel Muallem

doi:10.1126/scisignal.aat5018

Research ArticleION TRANSPORT

Modulation of Cl⁻ signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT

Laura Vachel¹,*,
Nikolay Shcheynikov¹,*,
Osamu Yamazaki¹,²,*,
Moran Fremder³,
Ehud Ohana ³,
View ORCID ProfileAran Son¹,
View ORCID ProfileDong Min Shin ⁴,
Ai Yamazaki-Nakazawa¹,
Chin-Rang Yang⁵,
View ORCID ProfileMark A. Knepper ⁵, and
Shmuel Muallem ¹,†

¹Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
²Apheresis and Dialysis Center/General Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan.
³Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.
⁴Department of Oral Biology, BK 21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea.
⁵Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

↵†Corresponding author. Email: shmuel.muallem{at}nih.gov

↵* These authors contributed equally to this work and are first co-authors.

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Science Signaling 30 Oct 2018:
Vol. 11, Issue 554, eaat5018
DOI: 10.1126/scisignal.aat5018

Laura Vachel

1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Nikolay Shcheynikov

1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Osamu Yamazaki

1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

2Apheresis and Dialysis Center/General Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan.

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Moran Fremder

3Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.

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Ehud Ohana

3Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.

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Aran Son

1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Dong Min Shin

4Department of Oral Biology, BK 21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea.

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Ai Yamazaki-Nakazawa

1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Chin-Rang Yang

5Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Mark A. Knepper

5Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Shmuel Muallem

1Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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For correspondence: shmuel.muallem@nih.gov

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Modulation of Cl⁻ signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT

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