Contents

Research Articles

• Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH

  By Dalee Zhou, Koji Ota, Charlee Nardin, Michelle Feldman, Adam Widman, Olivia Wind, Amanda Simon, Michael Reilly, Lonny R. Levin, Jochen Buck, Kazumasa Wakamatsu, Shosuke Ito, Jonathan H. Zippin

  Science Signaling06 Nov 2018 Full AccessRestricted Access

  Inhibitors of soluble adenylyl cyclase increase pigmentation and may reduce the risk of skin cancer.

  • Editor's Summary
  • Abstract
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• Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation

  By Jeffrey S. Smith, Lowell T. Nicholson, Jutamas Suwanpradid, Rachel A. Glenn, Nicole M. Knape, Priya Alagesan, Jaimee N. Gundry, Thomas S. Wehrman, Amber Reck Atwater, Michael D. Gunn, Amanda S. MacLeod, Sudarshan Rajagopal

  Science Signaling06 Nov 2018 Full AccessRestricted Access

  Small-molecule biased agonists of a chemokine receptor elicit distinct physiological outcomes.

  • Editor's Summary
  • Abstract
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• Engineering allosteric regulation in protein kinases

  By David Pincus, Jai P. Pandey, Zoë A. Feder, Pau Creixell, Orna Resnekov, Kimberly A. Reynolds

  Science Signaling06 Nov 2018 Full AccessRestricted Access

  Mutations in conserved surface regions facilitate the regulatory diversity of kinases.

  • Editor's Summary
  • Abstract
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