Contents
06 November 2018
Vol 11, Issue 555
Vol 11, Issue 555
Research Articles
- Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH
Inhibitors of soluble adenylyl cyclase increase pigmentation and may reduce the risk of skin cancer.
- Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation
Small-molecule biased agonists of a chemokine receptor elicit distinct physiological outcomes.
- Engineering allosteric regulation in protein kinases
Mutations in conserved surface regions facilitate the regulatory diversity of kinases.
Editors' Choice
- New connections: Taking advantage of bias
Biased chemokine receptor agonists and antagonists that target specific signaling pathways may provide therapeutic benefit.
About The Cover
Online Cover This week features a Research Article that describes a mechanism of rapidly regulating melanin production and skin pigmentation that does not require changes in gene expression or new protein synthesis. The image shows individuals with varying levels of skin pigmentation. [Image: Image Source/Alamy Stock Photo]