Research ArticleBiochemistry
Engineering allosteric regulation in protein kinases
- David Pincus1,*,†,
- Jai P. Pandey1,*,‡,
- Zoë A. Feder1,
- Pau Creixell2,3,4,5,
- Orna Resnekov6, and
- Kimberly A. Reynolds7,8,*,†
- 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 6Currently unaffiliated independent scientist.
- 7Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 8Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- ↵†Corresponding author. Email: pincus{at}wi.mit.edu (D.P.); kimberly.reynolds{at}utsouthwestern.edu (K.A.R.)
↵* These authors contributed equally to this work.
↵‡ Present address: Food and Drug Administration, Silver Spring, MD 20903, USA.
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Science Signaling 06 Nov 2018:
Vol. 11, Issue 555, eaar3250
DOI: 10.1126/scisignal.aar3250
