Research ArticleBiochemistry
Engineering allosteric regulation in protein kinases
- David Pincus1,*,†,
- View ORCID ProfileJai P. Pandey1,*,‡,
- Zoë A. Feder1,
- Pau Creixell2,3,4,5,
- Orna Resnekov6, and
- View ORCID ProfileKimberly A. Reynolds7,8,*,†
- 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 6Currently unaffiliated independent scientist.
- 7Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 8Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- ↵†Corresponding author. Email: pincus{at}wi.mit.edu (D.P.); kimberly.reynolds{at}utsouthwestern.edu (K.A.R.)
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Science Signaling 06 Nov 2018:
Vol. 11, Issue 555, eaar3250
DOI: 10.1126/scisignal.aar3250
Vol. 11, Issue 555, eaar3250
DOI: 10.1126/scisignal.aar3250
David Pincus
1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Jai P. Pandey
1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Zoë A. Feder
1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Pau Creixell
2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Orna Resnekov
6Currently unaffiliated independent scientist.
Kimberly A. Reynolds
7Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
8Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
