Engineering allosteric regulation in protein kinases

David Pincus; Jai P. Pandey; Zoë A. Feder; Pau Creixell; Orna Resnekov; Kimberly A. Reynolds

doi:10.1126/scisignal.aar3250

Research ArticleBiochemistry

Engineering allosteric regulation in protein kinases

David Pincus¹,*,†,
Jai P. Pandey¹,*,‡,
Zoë A. Feder¹,
Pau Creixell²,³,⁴,⁵,
Orna Resnekov⁶, and
Kimberly A. Reynolds⁷,⁸,*,†

¹Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
²David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁶Currently unaffiliated independent scientist.
⁷Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁸Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

↵†Corresponding author. Email: pincus{at}wi.mit.edu (D.P.); kimberly.reynolds{at}utsouthwestern.edu (K.A.R.)

↵* These authors contributed equally to this work.
↵‡ Present address: Food and Drug Administration, Silver Spring, MD 20903, USA.

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Science Signaling 06 Nov 2018:
Vol. 11, Issue 555, eaar3250
DOI: 10.1126/scisignal.aar3250

David Pincus

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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For correspondence: pincus@wi.mit.edu kimberly.reynolds@utsouthwestern.edu

Jai P. Pandey

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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ORCID record for Jai P. Pandey

Zoë A. Feder

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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Pau Creixell

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Orna Resnekov

Currently unaffiliated independent scientist.

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Kimberly A. Reynolds

Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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ORCID record for Kimberly A. Reynolds
For correspondence: pincus@wi.mit.edu kimberly.reynolds@utsouthwestern.edu

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