Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

Kristina B. Emdal; Anna-Kathrine Pedersen; Dorte B. Bekker-Jensen; Alicia Lundby; Shana Claeys; Katleen De Preter; Frank Speleman; Chiara Francavilla; Jesper V. Olsen

doi:10.1126/scisignal.aap9752

Research ResourceCancer

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

View ORCID ProfileKristina B. Emdal¹,²,*,
View ORCID ProfileAnna-Kathrine Pedersen¹,*,
Dorte B. Bekker-Jensen¹,
Alicia Lundby¹,³,
View ORCID ProfileShana Claeys⁴,
View ORCID ProfileKatleen De Preter⁴,
Frank Speleman⁴,
View ORCID ProfileChiara Francavilla ¹,⁵,†,‡, and
View ORCID ProfileJesper V. Olsen ¹,†,‡

¹Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
²Department of Biological Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
³Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
⁴Center for Medical Genetics Ghent, Cancer Research Institute Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
⁵Division of Molecular and Cellular Functions, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

↵‡Corresponding author. Email: chiara.francavilla{at}manchester.ac.uk (C.F.); jesper.olsen{at}cpr.ku.dk (J.V.O.)

↵* These authors contributed equally to this work.
↵† These authors contributed equally to this work.

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Science Signaling 20 Nov 2018:
Vol. 11, Issue 557, eaap9752
DOI: 10.1126/scisignal.aap9752

Kristina B. Emdal

1Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

2Department of Biological Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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ORCID record for Kristina B. Emdal

Anna-Kathrine Pedersen

1Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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Dorte B. Bekker-Jensen

1Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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Alicia Lundby

1Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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Shana Claeys

4Center for Medical Genetics Ghent, Cancer Research Institute Ghent, De Pintelaan 185, 9000 Ghent, Belgium.

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Katleen De Preter

4Center for Medical Genetics Ghent, Cancer Research Institute Ghent, De Pintelaan 185, 9000 Ghent, Belgium.

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Frank Speleman

4Center for Medical Genetics Ghent, Cancer Research Institute Ghent, De Pintelaan 185, 9000 Ghent, Belgium.

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Chiara Francavilla

1Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

5Division of Molecular and Cellular Functions, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

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For correspondence: chiara.francavilla@manchester.ac.uk jesper.olsen@cpr.ku.dk

Jesper V. Olsen

1Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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ORCID record for Jesper V. Olsen
For correspondence: chiara.francavilla@manchester.ac.uk jesper.olsen@cpr.ku.dk

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vol. 11 no. 557

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https://doi.org/10.1126/scisignal.aap9752

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Received September 18, 2017
Accepted September 17, 2018
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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

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