Contents
27 November 2018
Vol 11, Issue 558
Vol 11, Issue 558
Focus
- Thinking through acidic Ca2+ stores
Release of endolysosomal Ca2+ stores mediates glutamate-induced neuronal activity (Foster et al., in 27 November 2018 issue).
Research Articles
- Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling
Acidic Ca2+ store–mediated mGluR signaling underlies synaptic plasticity in hippocampal neurons.
- Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11–mediated protection of regulatory T cells
Aspirin stimulates production of the cytokine IL-11, which promotes regulatory T cell stability to suppress autoimmunity.
- β-Barrel outer membrane proteins suppress mTORC2 activation and induce autophagic responses
Bacterial outer membrane proteins with a β-barrel structure induce autophagy in macrophage and epithelial cells by deactivating mTORC2.
Editors' Choice
- Priming the liver for a feast after famine
Food perception activates a hypothalamus-to-liver pathway that prepares the liver for nutrient influx.
Erratum
About The Cover
Online Cover This week features a Research Article that shows that a low-dose aspirin regimen may benefit patients with multiple sclerosis, an autoimmune disease that affects the spinal cord. The image shows a colored scanning electron micrograph of a cross-section through a spinal cord, with the grey matter in brown and white matter in yellow. [Image: SPL/Science Source]