Research ArticleHost-Microbe Interactions

β-Barrel outer membrane proteins suppress mTORC2 activation and induce autophagic responses

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Science Signaling  27 Nov 2018:
Vol. 11, Issue 558, eaat7493
DOI: 10.1126/scisignal.aat7493

Barreling over mTORC2

Autophagy can be beneficial for clearing pathogen infection. Gram-negative bacteria commonly have outer membrane proteins with a β-barrel tertiary structure, which is also found in proteins localized to the outer membrane of mitochondria (which are evolutionarily descended from symbiotic bacteria). Chaudhary et al. showed that β-barrel outer membrane proteins were recognized by specific receptors on macrophages and epithelial cells, resulting in suppression of the multiprotein complex mTORC2 and induction of autophagy. Adding outer membrane proteins to mouse macrophages enabled clearance of Salmonella Typhimurium infection. Thus, the signaling pathways activated by outer membrane proteins may contribute to immune responses that promote pathogen clearance or autoimmune diseases.

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