04 December 2018
Vol 11, Issue 559

About The Cover

Cover image expansion

Online Cover This week features a Research Article (see also the related Focus) that describes how a p62 fragment generated by caspase-8 regulates responses to nutrient availability, rather than autophagy. The image shows a cell expressing full-length p62 (left), which localizes with Listeria monocytogenes ΔactA, and a cell expressing the p62 fragment, called p62TRM (right), which does not participate in xenophagy and does not colocalize with the infecting bacteria. Full-length p62 and p62TRM are green and the bacterium is red. [Image: Sanchez-Garrido et al./Science Signaling]