Contents
11 December 2018
Vol 11, Issue 560
Vol 11, Issue 560
Research Articles
- The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein
Rapid intervention with an miR-7 mimic may protect the brain in patients who have had a stroke.
- Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation
Preventing GRK2 from localizing to mitochondria lessens the damage induced by myocardial infarction.
- The β4 subunit of Cav1.2 channels is required for an optimal interferon response in cardiac muscle cells
A regulatory subunit of a voltage-gated calcium channel translocates to the nucleus to promote an antiviral response.
- Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1
Crk adaptor proteins mediate integrin signaling–induced T cell migration.
Editors' Choice
- Targeting PD-1
Loss of an E3 ubiquitin ligase that targets PD-1 for degradation leads to inefficient antitumor responses by T cells.
About The Cover
Online Cover This week features a Research Article that shows how an oligonucleotide mimicking the microRNA miR-7 limited brain damage and improved motor recovery in mice when administered either before or soon after cerebral ischemia. The image shows a brain MRI from a stroke patient. [Image: Puwadol Jaturawutthichai/shutterstock.com]