Research ArticleCell Biology

The β4 subunit of Cav1.2 channels is required for an optimal interferon response in cardiac muscle cells

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Science Signaling  11 Dec 2018:
Vol. 11, Issue 560, eaaj1676
DOI: 10.1126/scisignal.aaj1676

Channeling antiviral immunity?

The intracellular β4 subunit of the voltage-gated calcium channel Cav1.2 plays a major role in the proper localization and function of the pore-forming α subunit, but it has also been implicated in regulating gene expression in neurons and lymphocytes. Tammineni et al. found that β4 abundance and nuclear localization were increased in a cardiac cell line in response to treatment with type I interferon (IFN) or infection with dengue virus. The β4 subunit physically interacted with the transcriptional regulator IRF7 and was associated with the increased expression of IFN-stimulated genes. In cells overexpressing the β4 subunit, dengue virus replication was inhibited. Together, these data suggest that the β4 subunit may play a channel-independent role in the antiviral response.

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