Contents
18 December 2018
Vol 11, Issue 561
Vol 11, Issue 561
Research Articles
- 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein–coupled receptor D
Sensory neurons expressing the GPCR Mrgprd mediate the effects of a bioactive lipid to cause abdominal pain.
- CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity
Exclusion of a phosphatase from regions of antigen-receptor engagement facilitates mast cell activation.
- Spatially structured cell populations process multiple sensory signals in parallel in intact vascular endothelium
Clusters of endothelial cells exhibit distinct sensitivities to different agonists and cooperate to process multiple signals.
- All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics
The three IP3R isoforms produce Ca2+ puffs with largely indistinguishable features.
- ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation
The proteins that generate Ca2+ signals within the first second after T cell activation are identified.
Editors' Choice
- Controlling chemokine secretion
Activating the ion channel activity of TRPML2 on endosomes promotes cytokine secretion by macrophages.
About The Cover
Online Cover This week features a Research Article that identified a polyunsaturated fatty acid (PUFA) and a receptor that contribute to abdominal pain in a mouse model of irritable bowel syndrome (IBS). The authors found that the PUFA 5-oxoETE was more abundant in the colons of IBS patients with constipation than in those of healthy donors, that 5-oxoETE induced pain in mice, and that mice deficient in the receptor Mrgprd were less sensitive to the effects of 5-oxoETE. The image shows a mouse dorsal root ganglion expressing Mrgprd (green). [Image: Bautzova et al./Science Signaling]