Research ArticlePain

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein–coupled receptor D

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Science Signaling  18 Dec 2018:
Vol. 11, Issue 561, eaal2171
DOI: 10.1126/scisignal.aal2171

Inducing pain in IBS

A symptom of irritable bowel syndrome (IBS) that accompanies altered bowel function is abdominal pain. Noting that various polyunsaturated fatty acids (PUFAs) are implicated in modulating inflammation in patients with IBS, Bautzova et al. found that the abundance of the PUFA 5-oxoETE was selectively increased in colonic biopsies from patients with a subtype of IBS characterized by constipation (IBS-C). 5-oxoETE increased pain sensitivity in mice without eliciting inflammation and stimulated both mouse and human dorsal root ganglia neurons expressing the GPCR Mrgprd. Knockdown of Mrgprd in mice reduced the percentage of neurons that responded to 5-oxoETE and decreased pain sensitivity, suggesting that this PUFA may mediate abdominal pain in patients with IBS-C.

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