Research ArticleImmunology

CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity

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Science Signaling  18 Dec 2018:
Vol. 11, Issue 561, eaat0756
DOI: 10.1126/scisignal.aat0756

Mast cells get exclusive

The mast cell receptor FcεRI binds to antibody-bound antigens and then activates and recruits cytosolic kinases to stimulate allergic responses. Although receptor aggregation by multivalent antigens is a well-characterized mechanism of FcεRI activation, the receptor also responds to monovalent antigens. Felce et al. used imaging and functional analyses to show that the exclusion of a phosphatase from regions of the plasma membrane in which FcεRI was engaged by surface-bound, monovalent antigens led to receptor-induced kinase activity and mast cell stimulation. This form of receptor triggering may be combined with antigen-induced receptor aggregation-based signaling to extend the reactivity of mast cells to antigens.

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