Research ArticleImmunology CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity View ORCID ProfileJames H. Felce1,2,3,*, View ORCID ProfileErdinc Sezgin1,*, View ORCID ProfileMadina Wane1,2, View ORCID ProfileHeather Brouwer1,2, View ORCID ProfileMichael L. Dustin3,†, View ORCID ProfileChristian Eggeling1,†,‡, and View ORCID ProfileSimon J. Davis1,2,†1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.3Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.↵†Corresponding author. Email: simon.davis{at}imm.ox.ac.uk (S.J.D.); christian.eggeling{at}rdm.ox.ac.uk (C.E.); michael.dustin{at}kennedy.ox.ac.uk (M.L.D.)↵* These authors contributed equally to this work.↵‡ Present address: Institute of Applied Optics Friedrich-Schiller-University Jena and Leibniz Institute of Photonic Technology e.V., Jena, Germany. See allHide authors and affiliations Science Signaling 18 Dec 2018:Vol. 11, Issue 561, eaat0756DOI: 10.1126/scisignal.aat0756 James H. Felce 1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.3Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for James H. Felce Erdinc Sezgin 1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Erdinc Sezgin Madina Wane 1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Madina Wane Heather Brouwer 1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Heather Brouwer Michael L. Dustin 3Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Michael L. Dustin For correspondence: simon.davis@imm.ox.ac.uk christian.eggeling@rdm.ox.ac.uk michael.dustin@kennedy.ox.ac.uk Christian Eggeling 1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Christian Eggeling For correspondence: simon.davis@imm.ox.ac.uk christian.eggeling@rdm.ox.ac.uk michael.dustin@kennedy.ox.ac.uk Simon J. Davis 1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Simon J. Davis For correspondence: simon.davis@imm.ox.ac.uk christian.eggeling@rdm.ox.ac.uk michael.dustin@kennedy.ox.ac.uk Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 11 no. 561 DOI: https://doi.org/10.1126/scisignal.aat0756 PubMed: 30563863 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received January 22, 2018Resubmitted May 1, 2018Accepted November 30, 2018 . Copyright & Usage: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: December 2018 to January 2021 AbstractFullPdf Dec 20187878335151 Jan 2019165515980 Feb 20196405224 Mar 20191743220 Apr 20192843533 May 20191122716 Jun 2019912811 Jul 2019652510 Aug 201973288 Sep 2019663611 Oct 2019763614 Nov 2019743614 Dec 2019416726 Jan 2020211651 Feb 20201211349 Mar 202058743 Apr 202036541 May 202015319 Jun 202036035 Jul 202016536 Aug 202005327 Sep 202035725 Oct 202017024 Nov 202017148 Dec 202015237 Jan 202112416 View Full Text
CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity By James H. Felce, Erdinc Sezgin, Madina Wane, Heather Brouwer, Michael L. Dustin, Christian Eggeling, Simon J. Davis Science Signaling18 Dec 2018 Exclusion of a phosphatase from regions of antigen-receptor engagement facilitates mast cell activation. Supplementary Materials
CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity By James H. Felce, Erdinc Sezgin, Madina Wane, Heather Brouwer, Michael L. Dustin, Christian Eggeling, Simon J. Davis Science Signaling18 Dec 2018 Exclusion of a phosphatase from regions of antigen-receptor engagement facilitates mast cell activation. Supplementary Materials