CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity

James H. Felce; Erdinc Sezgin; Madina Wane; Heather Brouwer; Michael L. Dustin; Christian Eggeling; Simon J. Davis

doi:10.1126/scisignal.aat0756

Research ArticleImmunology

CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity

View ORCID ProfileJames H. Felce ¹,²,³,*,
View ORCID ProfileErdinc Sezgin ¹,*,
View ORCID ProfileMadina Wane¹,²,
View ORCID ProfileHeather Brouwer¹,²,
View ORCID ProfileMichael L. Dustin ³,†,
View ORCID ProfileChristian Eggeling ¹,†,‡, and
View ORCID ProfileSimon J. Davis ¹,²,†

¹MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
²Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
³Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.

↵†Corresponding author. Email: simon.davis{at}imm.ox.ac.uk (S.J.D.); christian.eggeling{at}rdm.ox.ac.uk (C.E.); michael.dustin{at}kennedy.ox.ac.uk (M.L.D.)

↵* These authors contributed equally to this work.
↵‡ Present address: Institute of Applied Optics Friedrich-Schiller-University Jena and Leibniz Institute of Photonic Technology e.V., Jena, Germany.

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Science Signaling 18 Dec 2018:
Vol. 11, Issue 561, eaat0756
DOI: 10.1126/scisignal.aat0756

James H. Felce

1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

3Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.

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Erdinc Sezgin

1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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ORCID record for Erdinc Sezgin

Madina Wane

1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

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Heather Brouwer

1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

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Michael L. Dustin

3Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.

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ORCID record for Michael L. Dustin
For correspondence: simon.davis@imm.ox.ac.uk christian.eggeling@rdm.ox.ac.uk michael.dustin@kennedy.ox.ac.uk

Christian Eggeling

1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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ORCID record for Christian Eggeling
For correspondence: simon.davis@imm.ox.ac.uk christian.eggeling@rdm.ox.ac.uk michael.dustin@kennedy.ox.ac.uk

Simon J. Davis

1MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

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ORCID record for Simon J. Davis
For correspondence: simon.davis@imm.ox.ac.uk christian.eggeling@rdm.ox.ac.uk michael.dustin@kennedy.ox.ac.uk

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CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity

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