Research ArticleCalcium signaling

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

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Science Signaling  18 Dec 2018:
Vol. 11, Issue 561, eaau0344
DOI: 10.1126/scisignal.aau0344

Different isoforms, similar Ca2+ puffs

Cells express three different isoforms of the inositol trisphosphate receptor (IP3R), which underlie Ca2+ signals ranging from local puffs to global waves. Lock et al. used CRISPR-Cas9 gene editing to create HEK-293 cell lines that expressed individual IP3R isoforms. Despite their reported divergent functional properties, each isoform produced Ca2+ puffs with similar characteristics. Future work is required to determine how these conserved Ca2+ puffs give rise to different global Ca2+ signals.

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