Contents
01 January 2019
Vol 12, Issue 562
Vol 12, Issue 562
Research Articles
- GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
A GPCR–Na/K-ATPase interaction alters metabolism and proliferation to enhance intestinal tumor formation.
- A posttranslational modification code for CFTR maturation is altered in cystic fibrosis
Protein misfolding prevents critical phosphorylation of the cystic fibrosis–associated protein CFTR.
- Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter
The sphingolipid S1P allosterically activates atypical protein kinase C to promote cell survival.
Review
- Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation
Postsynaptic anchoring of AMPA receptors determines synaptic strength as related to learning.
About The Cover
Online Cover This week features a Research Article that describes how a GPCR– Na/K-ATPase interaction alters metabolism and proliferation to enhance intestinal tumor formation. The image shows a hematoxylin and eosin stain of ileal Swiss rolls from a mouse model of colorectal cancer. [Image: Schneditz et al./Science Signaling]