Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter

Taketoshi Kajimoto; Alisha D. Caliman; Irene S. Tobias; Taro Okada; Caila A. Pilo; An-Angela N. Van; J. Andrew McCammon; Shun-ichi Nakamura; Alexandra C. Newton

doi:10.1126/scisignal.aat6662

Research ArticleBiochemistry

Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter

View ORCID ProfileTaketoshi Kajimoto ¹,²,*,
View ORCID ProfileAlisha D. Caliman¹,
Irene S. Tobias¹,
View ORCID ProfileTaro Okada ²,
Caila A. Pilo¹,
An-Angela N. Van¹,
View ORCID ProfileJ. Andrew McCammon ¹,
Shun-ichi Nakamura ², and
View ORCID ProfileAlexandra C. Newton ¹,*

¹Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.
²Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.

↵*Corresponding author. Email: anewton{at}ucsd.edu (A.C.N.); tkajimot{at}med.kobe-u.ac.jp (T.K.)

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Science Signaling 01 Jan 2019:
Vol. 12, Issue 562, eaat6662
DOI: 10.1126/scisignal.aat6662

Taketoshi Kajimoto

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

2Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.

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ORCID record for Taketoshi Kajimoto
For correspondence: anewton@ucsd.edu tkajimot@med.kobe-u.ac.jp

Alisha D. Caliman

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

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Irene S. Tobias

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

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Taro Okada

2Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.

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ORCID record for Taro Okada

Caila A. Pilo

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

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An-Angela N. Van

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

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J. Andrew McCammon

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

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Shun-ichi Nakamura

2Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.

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Alexandra C. Newton

1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.

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ORCID record for Alexandra C. Newton
For correspondence: anewton@ucsd.edu tkajimot@med.kobe-u.ac.jp

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