Contents
08 January 2019
Vol 12, Issue 563
Vol 12, Issue 563
Focus
- LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training
LIPID MAPS is a free resource dedicated to serving the lipid research community.
Research Articles
- Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure.
- Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo
A phosphoswitch in the tyrosine phosphatase PTPROt determines whether it stimulates or inhibits the kinase Src.
Editors' Choice
- Combination therapy is a game of strategy
For combination therapy, knowing the “how” and “when” is just as important as knowing the “what.”
About The Cover
Online Cover This week features a Research Article that describes how manganese-induced release of ASC-containing exosomes spreads inflammasome activation between microglial cells. The image shows a colored scanning electron micrograph of microglial cells. [Image: Steve Gschmeissner/Science Source]