15 January 2019
Vol 12, Issue 564

About The Cover

Cover image expansion

Online Cover This week features a Research Article that demonstrates that the adhesion protein CDH11 mediates contacts between macrophages and fibroblasts that enable macrophages to both promote the activation of fibroblasts into myofibroblasts and create a self-sustaining, profibrotic niche. The image shows the myofibroblast markers α-SMA (red) and fibronectin (green) in activated mouse lung fibroblasts. [Image: Lodyga et al./Science Signaling]