Contents
15 January 2019
Vol 12, Issue 564
Vol 12, Issue 564
Research Articles
- Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β
Adhesion with macrophages promotes the activation of fibroblasts into myofibroblasts and creates a self-sustaining profibrotic niche.
- Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events
Low-affinity ligands stimulate T cell responses when sequential antigen recognition events occur in nearby membrane regions.
- The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide–dependent neutrophil recruitment
A yeast cell wall component stimulates dendritic cells to recruit neutrophils and initiate inflammation in mice.
Editors' Choice
- mTORC1 goes sensorless
A metabolite of leucine regulates mTORC1 through acetylation of Raptor in certain cell types and tissues.
About The Cover
Online Cover This week features a Research Article that demonstrates that the adhesion protein CDH11 mediates contacts between macrophages and fibroblasts that enable macrophages to both promote the activation of fibroblasts into myofibroblasts and create a self-sustaining, profibrotic niche. The image shows the myofibroblast markers α-SMA (red) and fibronectin (green) in activated mouse lung fibroblasts. [Image: Lodyga et al./Science Signaling]