Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

Monika Lodyga; Elizabeth Cambridge; Henna M. Karvonen; Pardis Pakshir; Brian Wu; Stellar Boo; Melanie Kiebalo; Riitta Kaarteenaho; Michael Glogauer; Mohit Kapoor; Kjetil Ask; Boris Hinz

doi:10.1126/scisignal.aao3469

Research ArticleFibrosis

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

View ORCID ProfileMonika Lodyga¹,*,
View ORCID ProfileElizabeth Cambridge¹,*,
View ORCID ProfileHenna M. Karvonen¹,²,
Pardis Pakshir¹,³,
Brian Wu⁴,⁵,
Stellar Boo¹,
View ORCID ProfileMelanie Kiebalo¹,
Riitta Kaarteenaho²,
Michael Glogauer⁶,
View ORCID ProfileMohit Kapoor⁴,⁵,
View ORCID ProfileKjetil Ask⁷, and
View ORCID ProfileBoris Hinz ¹,²,⁶,†

¹Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
²Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.
³Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
⁴Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.
⁵Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
⁶Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
⁷Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario L8N 4A6, Canada.

↵†Corresponding author. Email: boris.hinz{at}utoronto.ca

↵* These authors contributed equally to this work.

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Science Signaling 15 Jan 2019:
Vol. 12, Issue 564, eaao3469
DOI: 10.1126/scisignal.aao3469

Monika Lodyga

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

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ORCID record for Monika Lodyga

Elizabeth Cambridge

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

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ORCID record for Elizabeth Cambridge

Henna M. Karvonen

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.

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ORCID record for Henna M. Karvonen

Pardis Pakshir

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

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Brian Wu

4Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

5Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

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Stellar Boo

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

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Melanie Kiebalo

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

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ORCID record for Melanie Kiebalo

Riitta Kaarteenaho

2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.

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Michael Glogauer

6Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

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Mohit Kapoor

4Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

5Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

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Kjetil Ask

7Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario L8N 4A6, Canada.

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Boris Hinz

1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.

6Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

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ORCID record for Boris Hinz
For correspondence: boris.hinz@utoronto.ca

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vol. 12 no. 564

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https://doi.org/10.1126/scisignal.aao3469

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Received July 10, 2017
Accepted December 17, 2018
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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

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