Research ArticleFibrosis
Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β
- Monika Lodyga1,*,
- Elizabeth Cambridge1,*,
- Henna M. Karvonen1,2,
- Pardis Pakshir1,3,
- Brian Wu4,5,
- Stellar Boo1,
- Melanie Kiebalo1,
- Riitta Kaarteenaho2,
- Michael Glogauer6,
- Mohit Kapoor4,5,
- Kjetil Ask7, and
- Boris Hinz1,2,6,†
- 1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
- 2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.
- 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
- 4Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.
- 5Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
- 6Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
- 7Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario L8N 4A6, Canada.
- ↵†Corresponding author. Email: boris.hinz{at}utoronto.ca
↵* These authors contributed equally to this work.
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Science Signaling 15 Jan 2019:
Vol. 12, Issue 564, eaao3469
DOI: 10.1126/scisignal.aao3469
Vol. 12, Issue 564, eaao3469
DOI: 10.1126/scisignal.aao3469
Monika Lodyga
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
Elizabeth Cambridge
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
Henna M. Karvonen
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.
Pardis Pakshir
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
3Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
Brian Wu
4Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.
5Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Stellar Boo
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
Melanie Kiebalo
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
Riitta Kaarteenaho
2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.
Michael Glogauer
6Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
Mohit Kapoor
4Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.
5Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Kjetil Ask
7Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario L8N 4A6, Canada.
Boris Hinz
1Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
2Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.
6Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
