22 January 2019
Vol 12, Issue 565

About The Cover

Cover image expansion

Online Cover This week features a Review that discusses how assigning targets to kinases, particularly those with few or no known substrates, and functionally annotating the phosphoproteome will provide new biological and disease insights. A complementary Focus emphasizes the need to shift from genetics-based approaches to protein- and signaling-centric approaches to realize the potential of precision cancer medicine. The image shows a three-dimensional phylogenetic tree of kinases color-coded by family. The node size and illumination represent the number of known targets for each kinase. [Image: Tim Burykin/Sydney University, Sydney, Australia]