Contents
29 January 2019
Vol 12, Issue 566
Vol 12, Issue 566
Research Articles
- The pseudokinase domains of guanylyl cyclase–A and –B allosterically increase the affinity of their catalytic domains for substrate
Pseudokinase domains in natriuretic peptide receptors promote receptor activation through a conserved allosteric mechanism.
- The transcription factor SP3 drives TNF-α expression in response to Smac mimetics
The transcription factor SP3 mediates the cytotoxic effects of Smac mimetics in cancer cells.
Editors' Choice
- Immune suppression with complex III
Loss of mitochondrial complex III in regulatory T cells reduces their suppressive activity without affecting their survival.
About The Cover
Online Cover This week features a Research Article that demonstrates that the pseudokinase domains of the natriuretic peptide receptors GC-A and GC-B promote receptor activation through an allosteric mechanism that is conserved with catalytically active kinases. The image shows a homology model of the pseudokinase domain of GC-A with the R-spine (red), C-spine (green), and F helix (yellow) highlighted. [Image: Edmund et al./Science Signaling]