Contents
05 February 2019
Vol 12, Issue 567
Vol 12, Issue 567
Research Articles
- Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
Analysis of the cancer-associated fibroblast secretome identifies an angiogenesis-promoting factor.
- Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
Epigenetic therapy may induce tumor-suppressive Notch signaling in patients with small cell lung cancer.
- Inhibition of T cell activation and function by the adaptor protein CIN85
The adaptor CIN85 inhibits T cell activation through its association with the phosphatase Sts-2 after TCR stimulation.
Review
- Interrogating B cell signaling pathways: A quest for novel therapies for mantle cell lymphoma
Targeting B cell receptor signaling pathways may be effective at treating mantle cell lymphoma.
Editors' Choice
- Autophagy-independent p62 in metastatic melanoma
By pairing up with RNA-binding proteins, p62 promotes melanoma progression.
About The Cover
Online Cover This week features a Research Article that identifies an angiogenesis-promoting factor by analyzing the proteome and secretome of cancer-associated fibroblasts, an abundant cell population in the tumor stroma. The image shows human breast cancer-associated fibroblasts stained for actin (magenta), vimentin (blue), and nuclei (white). [Image: F. Kugeratski/Cancer Research UK Beatson Institute, Glasgow, UK]