Contents

Research Articles

• Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

  By Fernanda G. Kugeratski, Samuel J. Atkinson, Lisa J. Neilson, Sergio Lilla, John R. P. Knight, Jens Serneels, Amelie Juin, Shehab Ismail, David M. Bryant, Elke K. Markert, Laura M. Machesky, Massimiliano Mazzone, Owen J. Sansom, Sara Zanivan

  Science Signaling05 Feb 2019 Full AccessRestricted Access

  Analysis of the cancer-associated fibroblast secretome identifies an angiogenesis-promoting factor.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials

• Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

  By Arnaud Augert, Emily Eastwood, Ali H. Ibrahim, Nan Wu, Eli Grunblatt, Ryan Basom, Denny Liggitt, Keith D. Eaton, Renato Martins, John T. Poirier, Charles M. Rudin, Francesca Milletti, Wei-Yi Cheng, Fiona Mack, David MacPherson

  Science Signaling05 Feb 2019 Full AccessRestricted Access

  Epigenetic therapy may induce tumor-suppressive Notch signaling in patients with small cell lung cancer.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials

• Inhibition of T cell activation and function by the adaptor protein CIN85

  By Mei Suen Kong, Akiko Hashimoto-Tane, Yusuke Kawashima, Machie Sakuma, Tadashi Yokosuka, Kohei Kometani, Reiko Onishi, Nick Carpino, Osamu Ohara, Tomohiro Kurosaki, Kia Kien Phua, Takashi Saito

  Science Signaling05 Feb 2019 Full AccessRestricted Access

  The adaptor CIN85 inhibits T cell activation through its association with the phosphatase Sts-2 after TCR stimulation.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials