Contents
Vol 12, Issue 568
Research Articles
- Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO
Bacterial infection induces macrophages to produce mitochondrial reactive oxygen species that covalently link NEMO molecules.
- Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration
Targeting inflammation and necrosis pathways may prevent chemotherapy-associated retinal damage.
- An immunoproteomic approach to characterize the CAR interactome and signalosome
The total length of CAR intracellular domains determines interactions with endogenous proteins to promote TCR signaling.
Editors' Choice
- EGFR signaling moves infection
A viral EGF homolog increases the migration of cells infected with vaccinia virus to promote viral spread.
About The Cover

Online Cover This week features a Research Article that describes how reactive oxygen species that are produced in the mitochondria of macrophages promote inflammatory signaling in the cytoplasm. The image shows a colored transmission electron micrograph of mitochondria. [Image: Steve Gschmeissner/Science Source]