Contents

Research Articles

• Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO

  By Marc Herb, Alexander Gluschko, Katja Wiegmann, Alina Farid, Anne Wolf, Olaf Utermöhlen, Oleg Krut, Martin Krönke, Michael Schramm

  Science Signaling12 Feb 2019 Full AccessRestricted Access

  Bacterial infection induces macrophages to produce mitochondrial reactive oxygen species that covalently link NEMO molecules.

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• Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration

  By Mariacarmela Allocca, Joshua J. Corrigan, Aprotim Mazumder, Kimberly R. Fake, Leona D. Samson

  Science Signaling12 Feb 2019 Full AccessRestricted Access

  Targeting inflammation and necrosis pathways may prevent chemotherapy-associated retinal damage.

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• An immunoproteomic approach to characterize the CAR interactome and signalosome

  By Maria C. Ramello, Ismahène Benzaïd, Brent M. Kuenzi, Maritza Lienlaf-Moreno, Wendy M. Kandell, Daniel N. Santiago, Mibel Pabón-Saldaña, Lancia Darville, Bin Fang, Uwe Rix, Sean Yoder, Anders Berglund, John M. Koomen, Eric B. Haura, Daniel Abate-Daga

  Science Signaling12 Feb 2019 Full AccessRestricted Access

  The total length of CAR intracellular domains determines interactions with endogenous proteins to promote TCR signaling.

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