Research ArticleDRUG TOXICITY
Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration
- Mariacarmela Allocca1,2,
- Joshua J. Corrigan1,2,
- Aprotim Mazumder1,2,
- Kimberly R. Fake1,2, and
- Leona D. Samson1,2,3,4,*
- 1Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
- 2Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
- 3Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
- 4David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
- ↵*Corresponding author. Email: lsamson{at}mit.edu
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Science Signaling 12 Feb 2019:
Vol. 12, Issue 568, eaau9216
DOI: 10.1126/scisignal.aau9216
