Contents

Research Articles

• Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

  By Zack Zurawski, Analisa D. Thompson Gray, Lillian J. Brady, Brian Page, Emily Church, Nicholas A. Harris, Michael R. Dohn, Yun Young Yim, Karren Hyde, Douglas P. Mortlock, Carrie K. Jones, Danny G. Winder, Simon Alford, Heidi E. Hamm

  Science Signaling19 Feb 2019 Full AccessRestricted Access

  Genetic ablation of Gβγ-SNARE signaling produces stress- and depression-related behaviors.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

  By Sumit J. Bandekar, Nadia Arang, Ena S. Tully, Brittany A. Tang, Brenna L. Barton, Sheng Li, J. Silvio Gutkind, John J. G. Tesmer

  Science Signaling19 Feb 2019 Full AccessRestricted Access

  Structural analysis of the RhoGEF Trio reveals modes of its activation in patients with cancer.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation

  By Shin-ichi Kano, Eric Y. Choi, Eisuke Dohi, Swati Agarwal, Daniel J. Chang, Ashley M. Wilson, Brian D. Lo, Indigo V. L. Rose, Santiago Gonzalez, Takashi Imai, Akira Sawa

  Science Signaling19 Feb 2019 Full AccessRestricted Access

  Glutathione S-transferases in astrocytes enhance microglia activation during brain inflammation.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials