Contents
19 February 2019
Vol 12, Issue 569
Vol 12, Issue 569
Research Articles
- Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes
Genetic ablation of Gβγ-SNARE signaling produces stress- and depression-related behaviors.
- Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential
Structural analysis of the RhoGEF Trio reveals modes of its activation in patients with cancer.
- Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation
Glutathione S-transferases in astrocytes enhance microglia activation during brain inflammation.
Editors' Choice
- Build them up, break them down
Cancer and stromal cells release signals that manipulate the vasculature to promote tumor metastasis or growth.
About The Cover
Online Cover This week features a Research Article that describes how stress- and depression-related behaviors arise in mice that have been genetically altered so that presynaptic Gβγ can no longer inhibit vesicle exocytosis. The image shows an artist's rendition of a synapse. [Image: KateStudio/shutterstock.com]