Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation

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Science Signaling  19 Feb 2019:
Vol. 12, Issue 569, eaar2124
DOI: 10.1126/scisignal.aar2124

Glutathione S-transferases enhance astrocyte-microglia communication

Astrocytes and microglia contribute to inflammatory responses in the brain. Kano et al. found that the glutathione S-transferases GSTM1 and GSTT2 contributed to astrocyte-mediated enhancement of microglia activation during brain inflammation. Knocking down either enzyme specifically in astrocytes reduced microglia activation in the brains of mice responding to systemic challenge with lipopolysaccharide (LPS). Coculture experiments with primary astrocytes and a microglial cell line showed that GSTM1 was required in astrocytes for nuclear factor κB (NF-κB)–mediated production of the proinflammatory factors GM-CSF and CCL2, which stimulate microglia activation. These findings identify a role for GSTM1 in enabling astrocytes to promote microglia activation during brain inflammation.

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