Contents
26 February 2019
Vol 12, Issue 570
Vol 12, Issue 570
Research Articles
- Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition
Inhibiting mTOR may reverse TGF-β–induced metastatic traits and drug resistance in carcinoma cells.
- Immunometabolism regulates TCR recycling and iNKT cell functions
Glycolysis augments T cell receptor recycling to promote downstream signaling and interferon-γ responses in iNKT cells.
Review
- Specificity, versatility, and control of TGF-β family signaling
Molecular function and pathway cross-talk in TGF-β signaling reveal its complexity and open questions.
Editors' Choice
- Linking lysosomes to stem cell differentiation
Lysosomal signaling enables stem cell differentiation by sequestering the transcription factor Tfe3 in the cytoplasm.
About The Cover
Online Cover This week features a Research Article showing that inhibiting mTOR may reverse TGF-β–induced metastasis and drug resistance in carcinoma cells. The image shows immunofluorescent staining for fibronectin (green) and F-actin (red) in mammary epithelial cells upon TGF-β receptor inhibition after long-term culture with TGF-β ligand. [Image: Katsuno et al./ Science Signaling]