Research ArticleImmunometabolism

Immunometabolism regulates TCR recycling and iNKT cell functions

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Science Signaling  26 Feb 2019:
Vol. 12, Issue 570, eaau1788
DOI: 10.1126/scisignal.aau1788

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Glycolysis promotes recycling

Lymphocyte functions are linked to activation of cellular metabolic pathways. Yet, it remains unclear how metabolism influences the activity of invariant natural killer T (iNKT) cells, which express a T cell receptor with limited diversity. Fu et al. found that effector iNKT cells from the spleen and liver, which had an activated cell surface phenotype, were more glycolytic than naïve CD4+ T cells. T cell receptor stimulation of iNKT cells further increased glycolysis, which promoted the production of the proinflammatory cytokine interferon-γ. Pharmacological inhibitors of glycolysis reduced T cell receptor signaling and recycling to sites of antigen recognition at the cell surface. Thus, glycolysis may augment iNKT cell activation by sustaining the density of cell surface T cell receptor.

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