05 March 2019
Vol 12, Issue 571

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows how RAS signaling adaptor proteins present in excitatory neurons mediate the SHP2 mutant–associated cognitive phenotypes of Noonan syndrome. The image shows merged immunofluorescent staining for phosphorylated ERK (red) in SHP2-mutant excitatory neurons (green) in mouse hippocampal slices. [Image: Ryu et al./Science Signaling]