Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

Isabel Wilhelm; Ella Levit-Zerdoun; Johanna Jakob; Sarah Villringer; Marco Frensch; Rudolf Übelhart; Alessia Landi; Peter Müller; Anne Imberty; Roland Thuenauer; Julie Claudinon; Hassan Jumaa; Michael Reth; Hermann Eibel; Elias Hobeika; Winfried Römer

doi:10.1126/scisignal.aao7194

Research ArticleHost-Pathogen Interactions

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

Isabel Wilhelm¹,²,³,*,
Ella Levit-Zerdoun⁴,⁵,⁶,*,
Johanna Jakob⁷,
Sarah Villringer¹,³,
Marco Frensch¹,³,⁵,
Rudolf Übelhart⁷,
Alessia Landi¹,³,
Peter Müller¹,³,
Anne Imberty⁸,
Roland Thuenauer¹,³,
Julie Claudinon¹,³,
Hassan Jumaa⁷,
Michael Reth¹,³,⁴,
Hermann Eibel⁹,¹⁰,
Elias Hobeika⁷,†,‡, and
Winfried Römer¹,²,³,†,‡

¹Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
²Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany.
³Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.
⁴Max Planck Institute of Immunology and Epigenetics Freiburg, 79108 Freiburg, Germany.
⁵International Max Planck Research School (IMPRS), Max Planck Institute of Immunobiology and Epigenetics Freiburg, 79108 Freiburg, Germany.
⁶German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Center (DKFZ), Heidelberg, Institute of Molecular Medicine and Cell Research, 79104 Freiburg, Germany.
⁷Institute for Immunology, University Medical Centre Ulm, 89081 Ulm, Germany.
⁸Univ. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.
⁹CCI-Center for Chronic Immunodeficiency (CCI), University Medical Centre, 79106 Freiburg, Germany.
¹⁰Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

↵‡Corresponding author. Email: elias.hobeika{at}uni-ulm.de (E.H.); winfried.roemer{at}bioss.uni-freiburg.de (W.R.)

↵* These authors contributed equally to this work.
↵† These senior authors contributed equally to this work.

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Sci. Signal. 05 Mar 2019:
Vol. 12, Issue 571, eaao7194
DOI: 10.1126/scisignal.aao7194

Isabel Wilhelm

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

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Ella Levit-Zerdoun

Max Planck Institute of Immunology and Epigenetics Freiburg, 79108 Freiburg, Germany.International Max Planck Research School (IMPRS), Max Planck Institute of Immunobiology and Epigenetics Freiburg, 79108 Freiburg, Germany.German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Center (DKFZ), Heidelberg, Institute of Molecular Medicine and Cell Research, 79104 Freiburg, Germany.

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Johanna Jakob

Institute for Immunology, University Medical Centre Ulm, 89081 Ulm, Germany.

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Sarah Villringer

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

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Marco Frensch

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.International Max Planck Research School (IMPRS), Max Planck Institute of Immunobiology and Epigenetics Freiburg, 79108 Freiburg, Germany.

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Rudolf Übelhart

Institute for Immunology, University Medical Centre Ulm, 89081 Ulm, Germany.

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Alessia Landi

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

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Peter Müller

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

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Anne Imberty

Univ. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.

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Roland Thuenauer

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

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Julie Claudinon

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

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Hassan Jumaa

Institute for Immunology, University Medical Centre Ulm, 89081 Ulm, Germany.

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Michael Reth

Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.Max Planck Institute of Immunology and Epigenetics Freiburg, 79108 Freiburg, Germany.

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Hermann Eibel

CCI-Center for Chronic Immunodeficiency (CCI), University Medical Centre, 79106 Freiburg, Germany.Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

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Elias Hobeika

Institute for Immunology, University Medical Centre Ulm, 89081 Ulm, Germany.

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For correspondence: elias.hobeika@uni-ulm.dewinfried.roemer@bioss.uni-freiburg.de

Winfried Römer

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For correspondence: elias.hobeika@uni-ulm.dewinfried.roemer@bioss.uni-freiburg.de

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vol. 12 no. 571

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https://doi.org/10.1126/scisignal.aao7194

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Received August 18, 2017
Resubmitted September 11, 2017
Accepted February 15, 2019

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

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