Contents
12 March 2019
Vol 12, Issue 572
Vol 12, Issue 572
Focus
- Eye on ion channels in immune cells
A recent cross-disciplinary meeting highlighted the importance of ion channels and fluxes in immunity.
Research Articles
- Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Manganese exposure promotes α-synuclein propagation, neuroinflammation, and neurodegeneration.
- Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors
Inactive conformations of α1B-AR and β2-AR are structurally similar but exhibit distinct pharmacological properties.
Editors' Choice
- Linking Mn2+, α-synuclein, and neuroinflammation
Several studies elucidate the molecular links between manganese exposure and Parkinson’s disease.
About The Cover
Online Cover This week features a Research Article that shows how manganese exposure, associated with Parkinson's disease, promotes the transfer of α-synuclein between neurons and microglia, which induce inflammation and neuronal cell death. The image shows immunofluorescent staining for exosomes (green) and a marker of caveolae-mediated endocytosis (red) in primary murine microglial cells. [Image: Harischandra et al./Science Signaling]