Research ArticleInnate Immunity
HIPK2 is necessary for type I interferon–mediated antiviral immunity
- View ORCID ProfileLili Cao1,*,
- View ORCID ProfileGuang Yang2,3,*,
- Shandian Gao2,
- View ORCID ProfileChunxia Jing4,
- View ORCID ProfileRuth R. Montgomery5,
- Yuxin Yin1,
- Penghua Wang2,6,
- View ORCID ProfileErol Fikrig2,7,†, and
- View ORCID ProfileFuping You1,†
- 1Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China.
- 2Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 208022, USA.
- 3Department of Parasitology, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601, Huangpu Avenue West, Guangzhou, Guangdong 510632, China.
- 4Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China.
- 5Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA.
- 6Department of Immunology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA.
- 7Howard Hughes Medical Institute, Chevy Chase, MA 20815, USA.
- ↵†Corresponding author. Email: fupingyou{at}hsc.pku.edu.cn (F.Y.); erol.fikrig{at}yale.edu (E.F.)
↵* These authors contributed equally to this work.
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Science Signaling 19 Mar 2019:
Vol. 12, Issue 573, eaau4604
DOI: 10.1126/scisignal.aau4604
Vol. 12, Issue 573, eaau4604
DOI: 10.1126/scisignal.aau4604
Lili Cao
1Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China.
Guang Yang
2Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 208022, USA.
3Department of Parasitology, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601, Huangpu Avenue West, Guangzhou, Guangdong 510632, China.
Shandian Gao
2Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 208022, USA.
Chunxia Jing
4Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Ruth R. Montgomery
5Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA.
Yuxin Yin
1Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China.
Penghua Wang
2Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 208022, USA.
6Department of Immunology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA.
Erol Fikrig
2Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 208022, USA.
7Howard Hughes Medical Institute, Chevy Chase, MA 20815, USA.
Fuping You
1Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China.
