Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin

Roman Fudim; Michal Szczepek; Johannes Vierock; Arend Vogt; Andrea Schmidt; Gunnar Kleinau; Paul Fischer; Franz Bartl; Patrick Scheerer; Peter Hegemann

doi:10.1126/scisignal.aav4203

Research ArticleStructural Biology

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin

Roman Fudim¹,*,
Michal Szczepek²,*,
Johannes Vierock¹,
Arend Vogt¹,
Andrea Schmidt²,
Gunnar Kleinau²,
Paul Fischer¹,
Franz Bartl ³,
Patrick Scheerer ²,†, and
Peter Hegemann ¹,†

¹Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
²Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.
³Biophysical Chemistry, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

↵†Corresponding author. Email: patrick.scheerer{at}charite.de (P.S.); hegemann{at}rz.hu-berlin.de (P.H.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Signaling 19 Mar 2019:
Vol. 12, Issue 573, eaav4203
DOI: 10.1126/scisignal.aav4203

Roman Fudim

Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Roman Fudim

Michal Szczepek

Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Johannes Vierock

Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Arend Vogt

Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Arend Vogt

Andrea Schmidt

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Andrea Schmidt

Gunnar Kleinau

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paul Fischer

Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Franz Bartl

Biophysical Chemistry, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patrick Scheerer

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Patrick Scheerer
For correspondence: patrick.scheerer@charite.de hegemann@rz.hu-berlin.de

Peter Hegemann

Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Peter Hegemann
For correspondence: patrick.scheerer@charite.de hegemann@rz.hu-berlin.de

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin

Plain text

Vertical Tabs

Science Signaling

Article Tools