Research ArticleStructural Biology
Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin
- Roman Fudim1,*,
- Michal Szczepek2,*,
- Johannes Vierock1,
- Arend Vogt1,
- Andrea Schmidt2,
- Gunnar Kleinau2,
- Paul Fischer1,
- Franz Bartl3,
- Patrick Scheerer2,†, and
- Peter Hegemann1,†
- 1Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
- 2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.
- 3Biophysical Chemistry, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
- ↵†Corresponding author. Email: patrick.scheerer{at}charite.de (P.S.); hegemann{at}rz.hu-berlin.de (P.H.)
↵* These authors contributed equally to this work.
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Science Signaling 19 Mar 2019:
Vol. 12, Issue 573, eaav4203
DOI: 10.1126/scisignal.aav4203
Vol. 12, Issue 573, eaav4203
DOI: 10.1126/scisignal.aav4203
Roman Fudim
1Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Michal Szczepek
2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.
Johannes Vierock
1Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Arend Vogt
1Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Andrea Schmidt
2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.
Gunnar Kleinau
2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.
Paul Fischer
1Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Franz Bartl
3Biophysical Chemistry, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Patrick Scheerer
2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute for Medical Physics and Biophysics, Group Protein X-ray Crystallography & Signal Transduction, Charitéplatz 1, D-10117 Berlin, Germany.
Peter Hegemann
1Experimental Biophysics, Institute for Biology, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
