FocusInnate Immunity

Regulation of type I interferon: It’s HIP to be K2

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Science Signaling  19 Mar 2019:
Vol. 12, Issue 573, eaaw8549
DOI: 10.1126/scisignal.aaw8549

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Abstract

Uncontrolled expression of type I interferon (IFN-I) drives autoimmunity, necessitating the need for tight regulation. In this issue, Cao et al. reveal a role for the kinase HIPK2 in the transcriptional control of IFN-I during antiviral immune responses.

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