Contents
26 March 2019
Vol 12, Issue 574
Vol 12, Issue 574
Research Articles
- Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo
Sperm maturation requires keeping protamine 2 dephosphorylated to enable tight DNA packaging.
- Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
New antibodies to the opioid receptor NOP reveal the signaling diversity of its agonists.
Review
- Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death
Enzymatically oxidized phospholipids have important functions in normal physiology and disease states.
Editors' Choice
- Activating cGAS at the right time and place
Plasma membrane localization and acetylation ensure the appropriate activation of the DNA sensor cGAS.
About The Cover
Online Cover This week features a Research Article that suggests that the phosphorylation state of protamine 2, a protein required for tightly packaging DNA and for maintaining normal sperm head shape, regulates sperm maturation. The image is an illustration of human sperm. [Image: Sebastian Kaulitzki/shutterstock.com]