Research ArticlePharmacology

Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists

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Science Signaling  26 Mar 2019:
Vol. 12, Issue 574, eaau8072
DOI: 10.1126/scisignal.aau8072

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Delineating NOP agonists

The nociceptin/orphanin FQ peptide (NOP) receptor is the least well-characterized member of the opioid receptor family. Mann et al. developed phosphosite-specific antibodies for the NOP receptor and then analyzed in cultured cells and in mice the physical and temporal patterns of its activation, which differed in response to various agonists. Because NOP receptors are involved in various physiological processes—from learning and food intake to cardiovascular function and pain perception—these antibody tools and initial insights into agonist-specific NOP receptor activity should have broad biological and clinical implications.