Research ResourceBiochemistry

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

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Science Signaling  02 Apr 2019:
Vol. 12, Issue 575, eaat8388
DOI: 10.1126/scisignal.aat8388

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Profiling PRMT5

The enzyme PRMT5 methylates arginine residues in target proteins to modify their function. PRMT5 functions in various cellular processes and is implicated in cancer. Musiani et al. used advanced and modified proteomics to explore the substrate specificity of PRMT5 and identified a preferred target site (a glycine-sandwiched arginine), as well as previously unknown substrates of the enzyme. This resource therefore offers clues to the function of PRMT5 in normal physiology and potential ways to target it in disease.