Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3–stimulated murine basophils

Soichiro Yoshikawa; Masatsugu Oh-hora; Ryota Hashimoto; Toshihisa Nagao; Louis Peters; Mayumi Egawa; Takuya Ohta; Kensuke Miyake; Takahiro Adachi; Yohei Kawano; Yoshinori Yamanishi; Hajime Karasuyama

doi:10.1126/scisignal.aav2060

Research ArticleCALCIUM SENSING

Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3–stimulated murine basophils

Soichiro Yoshikawa ¹,*,
Masatsugu Oh-hora²,
Ryota Hashimoto³,
Toshihisa Nagao¹,
Louis Peters¹,⁴,
Mayumi Egawa¹,
Takuya Ohta¹,
Kensuke Miyake¹,
Takahiro Adachi⁵,
Yohei Kawano¹,
Yoshinori Yamanishi¹, and
Hajime Karasuyama ¹

¹Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
²Department of Biochemistry, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
³Department of Physiology, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan.
⁴Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
⁵Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

↵*Corresponding author. Email: yoshisou.mbch{at}tmd.ac.jp

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Science Signaling 09 Apr 2019:
Vol. 12, Issue 576, eaav2060
DOI: 10.1126/scisignal.aav2060

Soichiro Yoshikawa

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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For correspondence: yoshisou.mbch@tmd.ac.jp

Masatsugu Oh-hora

Department of Biochemistry, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.

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Ryota Hashimoto

Department of Physiology, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan.

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Toshihisa Nagao

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Louis Peters

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.Faculty of Medicine, Imperial College London, London SW7 2BX, UK.

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Mayumi Egawa

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Takuya Ohta

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Kensuke Miyake

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Takahiro Adachi

Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Yohei Kawano

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Yoshinori Yamanishi

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Hajime Karasuyama

Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

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Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3–stimulated murine basophils

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