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Stepping out of the shadow: STIM2 promotes IL-3–induced cytokine release

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Sci. Signal.  09 Apr 2019:
Vol. 12, Issue 576, eaax0210
DOI: 10.1126/scisignal.aax0210

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Abstract

Basophils are a small population of innate immune cells, but their release of the cytokine interleukin-4 (IL-4) is important for mounting an efficient immune response against distinct parasites. Yoshikawa et al. (in the 9 April 2019 issue) showed that whereas STIM1 is essential for IL-4 release after stimulation of FcεRI, STIM2 mediates a delayed IL-3/IL-33–induced IL-4 release independent of STIM1.

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