Corticosteroid receptor balance regulates life and death in cardiomyocytes

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Science Signaling  16 Apr 2019:
Vol. 12, Issue 577, eaaw8715
DOI: 10.1126/scisignal.aaw8715


  • Fig. 1 The balance between MR and GR in cardiomyocytes determines the outcome of DNA damage upon heart function.

    Cortisol signaling through MR and GR determines the outcome of DNA damage in cardiomyocytes. Removal of the GR leaves MR signaling unopposed, resulting in progressive loss of cardiomyocytes, LV dysfunction, and heart failure. DNA damage causes oxidative stress, impaired Ca2+ signaling, decreased cell survival, and increased cell death through apoptosis and necrosis. Unopposed GR signaling in the absence of MR preserves LV function in the face of DNA damage. In mice lacking GR, deletion of MR delays the onset of LV dysfunction and heart failure.


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