Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization

Miriam Eckstein; Martin Vaeth; Francisco J. Aulestia; Veronica Costiniti; Serena N. Kassam; Timothy G. Bromage; Pal Pedersen; Thomas Issekutz; Youssef Idaghdour; Amr M. Moursi; Stefan Feske; Rodrigo S. Lacruz

doi:10.1126/scisignal.aav4663

Research ArticleCalcium signaling

Differential regulation of Ca²⁺ influx by ORAI channels mediates enamel mineralization

Miriam Eckstein¹,
Martin Vaeth²,
Francisco J. Aulestia¹,
Veronica Costiniti¹,
Serena N. Kassam³,
Timothy G. Bromage¹,⁴,
Pal Pedersen⁵,
Thomas Issekutz⁶,
Youssef Idaghdour⁷,
Amr M. Moursi³,
Stefan Feske ², and
Rodrigo S. Lacruz ¹,*

¹Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.
²Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
³Department of Pediatric Dentistry, New York University College of Dentistry, New York, NY 10010, USA.
⁴Department of Biomaterials, New York University College of Dentistry, New York, NY 10010, USA.
⁵Carl Zeiss Microscopy, LLC, Thornwood, NY 10594, USA.
⁶Department of Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada.
⁷Biology Program, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.

↵*Corresponding author. Email: rodrigo.lacruz{at}nyu.edu

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Science Signaling 23 Apr 2019:
Vol. 12, Issue 578, eaav4663
DOI: 10.1126/scisignal.aav4663

Miriam Eckstein

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.

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Martin Vaeth

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

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Francisco J. Aulestia

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.

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Veronica Costiniti

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.

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Serena N. Kassam

Department of Pediatric Dentistry, New York University College of Dentistry, New York, NY 10010, USA.

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Timothy G. Bromage

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.Department of Biomaterials, New York University College of Dentistry, New York, NY 10010, USA.

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Pal Pedersen

Carl Zeiss Microscopy, LLC, Thornwood, NY 10594, USA.

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Thomas Issekutz

Department of Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada.

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Youssef Idaghdour

Biology Program, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.

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Amr M. Moursi

Department of Pediatric Dentistry, New York University College of Dentistry, New York, NY 10010, USA.

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Stefan Feske

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

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Rodrigo S. Lacruz

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.

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ORCID record for Rodrigo S. Lacruz
For correspondence: rodrigo.lacruz@nyu.edu

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