Research ArticleCalcium signaling

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

See allHide authors and affiliations

Science Signaling  30 Apr 2019:
Vol. 12, Issue 579, eaav1439
DOI: 10.1126/scisignal.aav1439

Balancing Ca2+ pools in proliferating cells

Cell proliferation is an energetically demanding process. During the cell cycle, mitochondrial fusion and mitochondrial Ca2+ uptake increase, both of which correlate with increased ATP production. Koval et al. found that the mitochondrial Ca2+ uniporter (MCU) was required to balance Ca2+ concentrations in the cytosol and mitochondria. Without the MCU, the excess cytosolic Ca2+ resulted in mitochondrial fission mediated by Drp1, reduced ATP output, and decreased cellular proliferation. Thus, the MCU enables ATP production to match energy demands during the cell cycle.

View Full Text

Stay Connected to Science Signaling